Baclofen Withdrawal/Toxicity

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FACTS

Withdrawal
Toxicity
pathophysiology: abrupt decrease in CNS GABA transmission
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HPI

Withdrawal
Toxicity
fevers
autonomic dysfunction (bradycardia, HTN)
seizures
rhabdomyolysis
spasticity
rigidity
hallucinations
rostral progression of hypotonia
respiratory depression
coma
seizures
no fevers/rigidity

PHYSICAL EXAM

Withdrawal
Toxicity
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IMAGING

Withdrawal
Toxicity
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A/P
Withdrawal
Toxicity
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