Huntington Disease

FACTS

  • accumulation of mutant huntingtin protein → early degeneration of dorsal striatum (Caudate / putamen).
  • other regions:
    • calcarine cortex
    • mesial temporal lobe

HPI

universal ROS

PHYSICAL EXAM

universal neuro exam

IMAGING

will see significant volume loss in frontal horns → box-car ventricle
A/P
* No neurosurgery