Oligodendroglioma

FACTS

  • represent 10% gliomas
  • age 35-40 years, M = F
  • WHO Grade II or III

HPI

  • seizures are a frequent presentation

PHYSICAL EXAM

IMAGING

  • will notice they grow from white matter and infiltrate cortex
  • higher hemorrhage risk compared other glial tumors
    A/P
    • Chemo: PCV (procarbazine, carmustine, vincristine)
      • 1p/19q heterozygosity loss associated w/ better response
    • Counsel:
      • prognosis highly depends on grade (low grade 74% 5 year survival, high grade 41% 5 year)
     

    Pathology

    • sheets of similar cells with “perinuclear halos”
    • Round nuclei with scant cytoplasm “chicken-wire vasculature”: occasional serpentine configuration, fried egg yolk appearing cells
    • IHC: GFAP+/S100+